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 Microfluidics and Microsensor Engineers  
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PUBLICATIONS

  1. B. H. Weigl, R. L. Bardell, T. Schulte, D. C. Cullen, J. Demas, "Modeling of microscale processes speeds development and enhances performance of medical diagnostic product", In Vitro Diagnostics Technology, June 2004, 41-49, invited.

  2. A.N. Lukyanov, V.P. Torchilin. Micelles from Lipid Derivatives of Water-Soluble Polymers as Delivery Systems for Poorly Soluble Drugs. Adv. Drug Deliv. Rev., 2004, v. 7, p. 1273-1289.

  3. N. Lukyanov, V.P. Torchilin. Tumor Delivery of Peptide and Protein Drugs. Am. Pharm. Rev., 2004, v. 7, p. 77-81.

  4. M. Shen, et al. "The effects of surface chemistry and adsorbed proteins on foreign body giant cell formation, TNF? release and procoagulant activity of monocytes on modified polystyrene surfaces." J Biomed Mater Res, 70, 533-541, 2004.

  5. B. H. Weigl, R. L. Bardell, "Microfluidics for Clinical Diagnostics - Promise and Current Reality", Laboratory Medicine, April 2004, 4(35), 233-237, invited review article.

  6. R. Wettstein, A.G. Tsai, D. Erni, A.N. Lukyanov, V.P. Torchilin, M. Intaglietta. Improving Microcirculation is more Effective than Substitution of Red Blood Cells to Correct Metabolic Disorder in Experimental Hemorrhagic Shock. Shock, 2004, v. 21, p. 235-240.

  7. A.N. Lukyanov, W.C. Hartner, V.P Torchilin. Increased Accumulation of PEG-PE Micelles in the Area of Experimental Myocardial Infarction in Rabbits. J. Control. Release, 2004, v. 94, p. 187-193.

  8. A.N. Lukyanov, R.M. Sawant, W.C. Hartner, V.P. Torchilin. PEGylated Dextran as Long-circulating Pharmaceutical Carrier. J. Biomat. Sci., Pol. Ed., 2004, v. 15, p. 621-630.

  9. A.N. Lukyanov, T.A. Elbayoumi, A.R. Chakilam, V.P. Torchilin. Tumor-targeted Liposomes: Doxorubicin-loaded Long-circulating Liposomes Modified with Anti-cancer Antibody. J. Control Release. 2004, v. 100, p. 135-144.

  10. B. H. Weigl, R. L. Bardell, C. R. Cabrera, "Lab-On-A-Chip For Drug Development", Advances in Drug Delivery Reviews 55 (2003) 349-377 (invited review article).

  11. M. Shen, et al. "Multivariate surface analysis characterization of plasma deposited tetraglyme surface chemistry for reduction of protein adsorption and monocyte adhesion." Langmuir, 19, 1692-1699, 2003.

  12. V.P. Torchilin, A.N. Lukyanov. Protein and Peptide Drug Delivery to and into Tumors: Challenges and Solutions. Drug Discov. Today, 2003, v. 8, p. 259-266.

  13. A.N. Lukyanov, Z. Gao, V.P. Torchilin. Micelles from Polyethylene glycol/phosphatidylethanolamine Conjugates for Tumor Drug Delivery. J. Control. Release, 2003, v. 9, p. 97-102.

  14. V.P. Torchilin, A.N. Lukyanov, Z. Gao, B. Papahadjopoulos-Sternberg. Immunomicelles ? Targeted Pharmaceutical Carriers for Poorly Soluble Drugs. Proc. Natl. Acad. Sci. USA, 2003, v.100, p. 6039-6044. (Editorial Highlight in Nat. Rev. Drug Discov., 2003, v. 2, p. 424).

  15. M. Ahmed, W.E. Monsky, G. Girnun, A. Lukyanov, G. D'Ippolito, J.B. Kruskal, K.E. Stuart, V.P. Torchilin, S.N. Goldberg. Radiofrequency Thermal Ablation Sharply Increases Intratumoral Liposomal Doxorubicin Accumulation and Tumor Coagulation. Cancer Res., 2003, v. 63, p. 6327-6333.

  16. B. H. Weigl and K. Hedine, "Lab-on-a-chip-based separation and detection technology for life science applications",   American Biotechnology Laboratory, Jan. 2002, Vol. 20:1 pp28-30

  17. S.N. Goldberg, G.D. Girnan, A.N. Lukyanov, M. Ahmed, W.L. Monsky, G.S. Gazelle, J.C. Huertas, K.E. Stuart, T. Jacobs, V.P. Torchillin, E.F. Halpern, J.B. Kruskal. Percutaneous Tumor Ablation: Increased Necrosis with Combined Radio- frequency Ablation and Intravenous Liposomal Doxorubicin in a Rat Breast Tumor Model. Radiology, 2002, v. 222, p.797-804.

  18. W.L. Monsky, J.B. Kruskal, A.N. Lukyanov, G.D. Girnun, M. Ahmed, G.S. Gazelle, J.C. Huertas, K.E. Stuart, V.P. Torchilin, S.N. Goldberg. Radio-frequency Ablation Increases Intratumoral Liposomal Doxorubicin Accumulation in a Rat Breast Tumor Model. Radiology, 2002, v. 224, p. 823-829.

  19. M. Shen, et al. "PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies." J Biomater Sci Polym Ed, 13, 367-390, 2002.

  20. M. Shen, et al. Invited talk. "PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies." 2002 UWEB Summer Scientific Symposium on "Non-Fouling Surfaces", Seattle, WA, 2002.

  21. A.N. Lukyanov, Z. Gao, L. Mazzola, V.P. Torchilin. Polyethylene Glycol-Diacyllipid Micelles Demonstrate Increased Accumulation in Subcutaneous Tumors in Mice. Pharm. Res., 2002, v. 19, p. 1424-1429.

  22. A.N. Lukyanov, S. Kare, A. Tsai, M. Intaglietta, V.P. Torchilin. Hemoglobin Modified with Polyethylene Glycol via p-Nitrophenylcarbonyl Groups: Preparation and Properties. In Proceed. Intl. Symp. Control. Rel. Bioact. Mater., 2002, v. 29, p. 666-667.

  23. B.H. Weigl, R. L. Bardell, T. H. Schulte, C. F. Battrell, J. Hayenga,   "Design and Rapid Prototyping of Thin-Film Laminate-Based Microfluidic Devices"  Biomedical Microdevices 2001, Vol. 3:4 pp 267-274, 2001, Kluwer Academic Publishers.

  24. B. H. Weigl, C. J. Morris, N. Kesler, P. Saltsman, R. L. Bardell,  "Well-Plate Formats and Microfluidics - Applications of Laminar Fluid Diffusion Interfaces to HTP Screening",   uTAS 2001. 383-384, D. J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers, Dordrecht, (2001).

  25. A. Hatch, A. Kamholz, K. Hawkins, M. Munson, E. Shilling, B. H. Weigl, P. Yager,   "A rapid diffusion immunoassay in a T-Sensor", Nature Biotechnology, Vol. 19, pp461-465, 2001.

  26. B. H. Weigl, R. L. Bardell, N. Kesler, C. J. Morris,   "Lab-on-a-chip sample preparation using Laminar Fluid Diffusion Interfaces - CFD Model Results and Fluidic Verification Experiments"  Fresenius Journal of Analytical Chemistry 2001, 371:97-105.

  27. M. Shen, et al. "Inhibition of monocyte adhesion and fibrinogen adsorption on glow discharge plasma deposited tetraethylene glycol dimethyl ether." J Biomater Sci Polym Ed, 12, 961-978, 2001.

  28. M. Shen and T.A. Horbett. "The effects of surface chemistry and adsorbed proteins on monocyte and macrophage adhesion to chemically modified polystyrene surfaces." J Biomed Mater Res, 57, 336-345, 2001.

  29. R. L. Bardell, B. H. Weigl, N. Kesler, T.H. Schulte, J. Hayenga, C.F. Battrell, "Microfluidic Disposables for Cellular and Chemical Detection - CFD Model Results and Fluidic Verification Experiments" ,   SPIE BIOS 2001, San Jose, January 2001.

  30. B. H. Weigl, R. L. Bardell, N. Kesler, C. J. Morris,   "Lab-on-a-chip sample preparation using Laminar Fluid Diffusion Interfaces - Computational Fluid Dynamics Model Results and Fluidic Verification Experiments",    SPIE BIOS 2001,   4265-02, 2001.

  31. Darling, Yager, Weigl, Kriebel, Mayes   "Integration Of Microelectrodes with Etched Microchannels for In-stream Electrochemical Analysis" .

  32. B. H. Weigl, "Microfluidic Devices Based on Laminar Fluid Diffusion Interface" smallTalk 2001,  San Diego,CA  fall  2001.

  33. V.P. Torchilin, T.S. Levchenko, A.N. Lukyanov, B.A. Khaw, A.L. Klibanov, R. Rammohan, G.P. Samokhin, K.R. Whiteman. p-Nitrophenylcarbonyl-PEG-PE-Liposomes: Fast and Simple Attachment of Specific Ligands, Including Monoclonal Antibodies to Distal Ends of PEG Chains via p-Nitrophenylcarbonyl Groups. Biochim. Biophys. Acta, 2001, v. 1511, p. 397-411.

  34. Ling-Sheng Jang, Nigel R. Sharma, Fred K. Forster, "The Effect of Particles on Performance of Fixed-Valve Micropumps," 4th International Symposium on Miniaturized Chemical and Biochemical Analysis Systems (mTAS), pp. 283-286, May 14-18, 2000, in Enschede, The Netherlands.

  35. R. L. Bardell  " The Diodicity Mechanism of Tesla-Type No-Moving-Parts Valves",   Ph.D. Dissertation, University of Washington, Seattle, 2000, (Adobe Acrobat PDF format, 4MB download)

  36. B. H.Weigl  "Microfluidics-based lab-on-a-chip systems",   IVD Technology Nov/Dec 2000, vol 6: pp.47-53, 2000.

  37. B. H. Weigl, A. Hatch, A. Kamholz, P. Yager ,"Novel Immunoassay Formats for Integrated Microfluidic Circuits - Diffusion Immunoassays (DIA)",  Micro- & Nanotechnology for Biomedical and Environmental Applications, SPIE 2000,   Proceedings of SPIE  3912:50-56.

  38. B. H. Weigl, R. L. Bardell, T. H. Schulte ,C. Williams, "Passive Microfluidics- Ultra-Low-Cost Plastic Disposable Lab-on-a-chips",  uTAS 2000 Proceedings, pp.299, 2000, D. J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers, Dordrecht, (2000)

  39. P. Yager, K. Cabrera, A. Hatch, K. Hawkins, M. Holl, A. Kamholz, Macounova, B. H. Weigl  "Analytical Devices Based on Transverse Transport in Microchannels",   uTAS 2000, p.15, May 2000. D. J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers, Dordrecht, (2000)

  40. A. Kamholz, B. H. Weigl, B. A. Finlayson, P. Yager,  "Quantitative Analysis of Molecular Interaction in a Microfluidici Channel: the T-Sensor", Anal. Chem. Vol 71, part 23, Dec 15, 1999.

  41. A. Hatch, B. H. Weigl, M. D. Zebert, P. Yager,  "Microfluidic approaches to immunoassays",   SPIE Conference Santa Clara, Sep 1999.

  42. B. H. Weigl, P. Yager,  "Microfluidic Diffusion-Based Separation and Detection",   Science,15:346-347,  January 1999.

  43. L. S. Jang, C. J. Morris, N. R. Sharma, R. L. Bardell and F. K. Forster,  "Transport of Particle-Laden Fluids Through Fixed-Valve Micropumps",   Proceedings of ASME IMECE, Nashville, TN, November 14-19, 1999.

  44. B.H. Weigl,   "Microfluidic diffusion-based separation and detection technology for Lab-on-a-chip Applications" (invited lecture), SmallTalk 99, Microfluidics and Microarray Conference, San Diego, CA, June 1999.

  45. B. H. Weigl, R. B. Darling, P. Yager, J. Kriebel, K. Mayes,   "Optical and electrochemical diffusion-based detection of analytes in complex samples using microfabricated flow structures (T-Sensors TM)",  Micro- & Nanofabricated Structures for Biomedical and Environmental Applications II, SPIE 1999,   3606:82-89.

  46. B.H. Weigl,   " Whole Blood Assays Using Microfluidics-Based T-Sensor Technology", Medical Design Online, http://news.medicaldesignonline.com/feature-articles/19990416-5922.html, 04-1999.

  47. B.H. Weigl,   "Tumor Marker Diagnostics Using Microfluidics-Based Separation and Detection Technology for Lab-on-a-Chip Applications" (invited presentation), First NASA & NCI Workshop on Sensors for Bio-Molecular Signatures, Pasadena. CA, June 2 4, 1999.

  48. P. Yager, M.A. Afromowitz, D. Bell, F.K. Forster, J.P. Brody, D. Qin, C. Cabrera, M. Holl, A. Kamholz, and B.H. Weigl, "Design of microfluidic sample preconditions systems for detection of biological agents in environmental samples" ,  SPIE, vol. 3515, 252-259 (1998).

  49. R.L. Bardell and F.K. Forster, "Impedances for Design of Microfluidic Systems", Proceedings of the Micro Total Analysis Systems '98 Conference, Banff, Alberta, October 13-16 1998.

  50. P. Yager, D. Bell, J.P. Brody, D. Qin, C. Cabrera, A. Kamholz, and B.H. Weigl, " Applying microfluidic chemical analytical systems to imperfect samples", uTAS 98, D.J. Harrison and A. van den Berg, eds., Kluwer Academic Publishers, Dordrecht, 207-212 (1998).

  51. B.H. Weigl, R. Darling, J. Kriebel, K. Mayes, P. Yager, Microfluidic diffusion based electrochemical detection using microfabricated flow structures (T-Sensors)

  52. M. Deshpande, J.R. Gilbert, F.K. Forster and R.L. Bardell, "Design Analysis of No Moving Parts Valves for Micropumps", MicroElectroMechanical Systems (MEMS), ASME IMECE, DSC-Vol. 66:153-8 (1998).

  53. B.H. Weigl, J. Kriebel, K. Mayes, P. Yager, CC Wu, M. Holl, M Kenny, D. Zebert,   " Simultaneous self-referencing analyte determination in complex sample solutions using microfabricated flow structures (T-Sensors)", uTAS 98, D.J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers, Dordrecht, (1998).

  54. R. Darling, P. Yager, B. H. Weigl, J. Kriebel, K. Mayes   "Integration of microelectrodes with etched microchannels for in-stream electrochemical analysis" (invited paper), uTAS 98, D.J. Harrison and A. van den Berg, eds. Kluwer Academic Publishers, Dordrecht, (1998).

  55. B.H. Weigl, J. Kriebel, K. Mayes, T. Buj, P. Yager,   "Whole blood diagnostics in standard gravity and microgravity using microfluidic structures (T-SensorsTM)" (invited paper), Microchimica Acta, 1998.

  56. K.C. Lee, A.N. Lukyanov, M.H. Gelb, P. Yager. Formation of High Axial Ratio Microstructures from Peptides Modified with Glutamic Acid Dialkyl Amides. Biochim. Biophys. Acta, 1998, v. 1371, p. 168-184.

  57. R.L. Bardell, N.R. Sharma, F.K. Forster, M.A. Afromowitz and R. Penney, "Designing High-Performance Micro-Pumps Based on No-Moving-Parts Valves", MicroElectroMechanical Systems, ASME IMECE, DSC-Vol. 62/HTD-Vol. 354:47-53 (1997).

  58. B.H. Weigl and P. Yager,   "Silicon-Microfabricated Diffusion-Based Optical Chemical Sensor, Sensors & Actuators", B Chemical, 38-39 (1997) pp 452-457.

  59. C.C. Wu, B. H. Weigl, T. Truong, M. Kenny,   "Comparison of data reduction schemes for fluorometric analysis of albumin on a si-chip", Academy of Clinical Laboratory Physicians and Scientists, 1997.

  60. P. Galambos, F. Forster, B. H. Weigl,  " A method for determination of pH Using a T-Sensor", Transducers 97, Category 5 -Chemical Sensors, 1997.

  61. B.H. Weigl, G. T. Hixon, P. Yager,   "Fluorescence and absorbance analyte sensing in whole blood based on diffusion separation in silicon-microfabricated flow structures" (invited paper), SPIE Proceedings, J. Lakowitz (ed.), Fluorescence Sensing Technology III, 1997.

  62. B.H. Weigl, G. T. Hixon, M. A Kenny, D. Zebert, S. Dwinnel, T. Buj, P. Yager,   "Fluorescence and absorption analyte sensing in whole blood based on diffusion separation in silicon-microfabricated flow structures (T-SensorsTM)" (invited paper), Biomedical Optics, Vol. 6, No.1, 1997.

  63. B.H. Weigl, G. van den Engh, R. Kaiser, E. Altendorf, and P. Yager,  " Rapid Sequential Chemical Analysis Using Multiple Fluorescent Reporter Beads", µTAS 96, Conference Proceedings, 1996.

  64. E. Altendorf, E. Iverson, D. Schutte, B. H. Weigl, T. Osborn, R. Sabeti, and P. Yager,   " Optical Flow Cytometry Utilizing Microfabricated Silicon Flow Channels", Advanced techniques in analytic Cytology (BIOS 96) SPIE Proc Vol 2678.

  65. B.H. Weigl, M. A. Holl, D. Schutte, J. P. Brody, and P. Yager,   "Diffusion-Based Optical Chemical Detection in Silicon Flow Structures", Analytical Methods and Instrumentation, µTAS 96 special edition, 1996.

  66. D. Zebert, M. A Kenny, J. S. Kenny, and B. H. Weigl,   "Serum Albumin Analysis Using AB 580, a Fluorescent Dye" , AACC National Meeting, Chicago, 1996.

  67. F.K. Forster, R.L. Bardell, M.A. Afromowitz, N.R. Sharma and A. Blanchard, "Design, Fabrication and Testing of Fixed-Valve Micro-Pumps", Proceedings of the ASME Fluids Engineering Division, IMECE, FED-Vol. 234:39-44. (1995).

  68. A.L. Klibanov, M.A. Slinkin, A.N. Lukyanov, V.P. Torchilin. Preparation of the Conjugates of Proteins with Chelate Polymers Using Water-Soluble Carbodiimide and N-Hydroxysulfosuccinimide. Vysokomol. Soed. (Russ.), 1989, v. 31A, p. 1173-1180.

  69. A.N. Lukyanov, A.L. Klibanov, A.V. Kabanov, V.P Torchilin, A.V. Levashov, K. Martinek. Covalent Binding of Phospholipids to Protein Globule in the System of Reverse Micelles. Bioorg. Chem. (Russ.), 1988, v. 14, p. 670-674.
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